1 00:00:09,279 --> 00:00:14,199 „The Laboratory of Biochemistry and Molecular Biology of Germ Cells“ 2 00:00:14,199 --> 00:00:17,000 deals with understanding the function of the oocyte (egg) 3 00:00:17,000 --> 00:00:21,800 and its fertilisation as well as the subsequent development of a new offspring. 4 00:00:45,240 --> 00:00:47,880 „We are interested in the molecular processes within the egg 5 00:00:47,880 --> 00:00:50,240 that lead to the development of a new healthy individual.“ 6 00:00:51,200 --> 00:00:56,840 We focus primarily on the study of cell division – meiosis and translation regulation, 7 00:00:56,840 --> 00:00:59,280 i.e. the transcription of DNA segments into proteins. 8 00:01:00,960 --> 00:01:04,159 For even the slightest errors during these processes 9 00:01:04,159 --> 00:01:07,840 lead to poor oocyte quality and impaired early embryonic development. 10 00:01:12,879 --> 00:01:16,319 „We use a laboratory mouse as mammalian model.“ 11 00:01:16,760 --> 00:01:21,120 For example, we have now created a mouse line where the female is “infertile”, 12 00:01:21,400 --> 00:01:27,079 which allows us to study the mechanisms that would cure this infertility. 13 00:01:29,079 --> 00:01:30,239 „Why is our work important? 14 00:01:30,239 --> 00:01:32,879 We are trying to understand the fundamental cellular processes of oocyte development. 15 00:01:33,120 --> 00:01:35,719 We are trying to solve the mammalian infertility 16 00:01:35,719 --> 00:01:37,959 as well as the abnormalities in oocyte and embryo development.