Our laboratory is focusing on the processes associated
with the formation of complex multicellular organisms,
with a special interest in the development of skull and craniofacial structures.
Particular attention is paid to the development of hard tissues,
including teeth and bones, and developmental disorders
– especially cleft lip and cleft palate.
We are using a wide range of experimental approaches
including tissue cultures or whole embryos.
Abnormalities related to dental tissues are becoming a burning scientific
and medical issue, mainly due to the increasing lifespan in human population
or changes in their dietary composition.
Our research focuses on the understanding of processes driving tooth development
through different developmental stages right from tooth initiation
The knowledge of these processes can help us to reveal the causes initiating
developmental abnormalities as well as acquired disorders.
To study these health-related issues, we are using a variety of model organisms.
Besides mice, we also employ selected species of reptiles
such as the chameleon or gecko, or the domestic pig as a representative of mammals.
Another major area of our research is the study of limb development
and formation of their structures.
We evaluate the physiological aspects
of developmental processes at both molecular and cellular level,
focusing on the associated developmental disorders
such as polydactyly or absence of fingers as well as finger deformations.
The best model organism to study limb development is the chicken embryo,
in which we are able perform large spectrum of micromanipulation techniques.
Some of our projects involve close cooperation with international research groups
or clinical departments.
One of these projects focuses on the evaluation of the effect of heavy metal particles
after their inhalation on target tissues in mice.
The goal is to identify the mechanisms through which the organism is able to respond
to the exposure of heavy metals and to promote the removal of nanoparticles from cells
using pharmaceutical tools, which could be used in future as a treatment.
Members of our laboratory has received several awards in various disciplines,
for example the MUNI Scientist award, the PhD Talent,
Dean’s award as well as the prize for the best research photograph.
Even our youngest students have been tremendously successful
in participating in the prestigious contests such as
High School Students’ Professional Activities or international competitions for students.
Our publications have appeared several times
on the front pages of influential scientific journals.
Further, we also participate in the organization of professional conferences
or practical workshops for students.
"For general public, we prepare lectures on various topics
related to the underlying causes of developmental disorders."