1 00:00:26,079 --> 00:00:32,320 Our goal is cutting-edge basic research in physiology, genetics, ecology, and evolution. 2 00:00:33,479 --> 00:00:36,880 A common feature of our research is the study of developmental processes 3 00:00:37,039 --> 00:00:39,840 using animals as model organisms. 4 00:00:41,079 --> 00:00:43,719 We are interested in how living organisms function 5 00:00:43,719 --> 00:00:45,759 and in the processes that take place within them. 6 00:00:48,719 --> 00:00:51,159 We investigate what controls these processes 7 00:00:51,159 --> 00:00:53,759 and what happens when they are disrupted. 8 00:00:57,119 --> 00:01:00,359 We explain interactions between individuals of the same species 9 00:01:00,600 --> 00:01:03,520 and their relationships with other species in a given environment. 10 00:01:04,000 --> 00:01:08,560 We also study which factors shaped organisms in different environments in the past 11 00:01:08,920 --> 00:01:12,359 and model possible changes in their behavior in the future. 12 00:01:21,280 --> 00:01:24,959 The aim of our research is to uncover the mechanisms of egg maturation, 13 00:01:25,239 --> 00:01:27,920 fertilization, and the development of a new individual. 14 00:01:30,239 --> 00:01:34,159 At the molecular level, we study how cells change during development, 15 00:01:34,319 --> 00:01:36,280 how they communicate with each other, and how they die. 16 00:01:36,959 --> 00:01:41,439 We focus on processes leading to developmental disorders at the level of DNA, 17 00:01:41,799 --> 00:01:44,040 chromosomes, cells, and entire embryos. 18 00:01:45,280 --> 00:01:48,159 We study the development of facial structures and limbs, 19 00:01:48,280 --> 00:01:51,760 especially hard tissues such as bones, cartilage, and teeth. 20 00:01:52,439 --> 00:01:55,359 We seek ways to reduce the occurrence of developmental disorders 21 00:01:55,519 --> 00:01:56,879 and to prevent them. 22 00:02:03,079 --> 00:02:07,760 We develop and test potential treatments for serious human diseases 23 00:02:08,120 --> 00:02:10,599 using our minipig model, bred by us, 24 00:02:11,159 --> 00:02:15,240 which is physiologically, genetically, and size-wise similar to humans. 25 00:02:16,520 --> 00:02:20,960 We focus on neurodegenerative diseases such as Huntington’s disease 26 00:02:21,199 --> 00:02:26,479 and amyotrophic lateral sclerosis, spinal cord injury, eye and ear diseases, 27 00:02:26,879 --> 00:02:31,800 as well as lifestyle-related diseases such as Crohn’s disease and skin cancer. 28 00:02:33,080 --> 00:02:37,919 Our results from preclinical testing of new cell and gene therapies 29 00:02:37,919 --> 00:02:43,360 help transfer novel therapeutic approaches into clinical trials. 30 00:02:48,520 --> 00:02:52,840 We study the diversity of life forms both in wild animal populations 31 00:02:53,240 --> 00:02:55,800 as well as in the microscopic world of their digestive tract. 32 00:02:57,159 --> 00:02:59,800 We investigate the origins of species diversity, 33 00:03:00,159 --> 00:03:02,199 why some species interbreed, 34 00:03:02,439 --> 00:03:04,240 their reproductive strategies, 35 00:03:04,520 --> 00:03:08,400 and their ability to cope with changing climatic conditions. 36 00:03:09,599 --> 00:03:10,960 We describe new species 37 00:03:10,960 --> 00:03:14,560 and actively participate in programs aimed to save the gene pools 38 00:03:14,560 --> 00:03:16,840 of genetically pure species and lineages. 39 00:03:18,080 --> 00:03:21,000 We contribute to the development of probiotic products. 40 00:03:21,479 --> 00:03:24,400 We search for more resilient bacteria for the food industry 41 00:03:24,800 --> 00:03:28,719 and seek to understand the relationship between the gut microbiome 42 00:03:29,039 --> 00:03:31,599 and serious human diseases. 43 00:03:33,879 --> 00:03:36,319 We conduct our research both in the field and in laboratories 44 00:03:36,560 --> 00:03:39,080 and collaborate with scientists from around the world. 45 00:03:42,879 --> 00:03:46,400 We publish our results in prestigious scientific journals, 46 00:03:46,960 --> 00:03:48,560 present them at conferences, 47 00:03:48,840 --> 00:03:53,039 and strive to make our work accessible to the general public. 48 00:03:55,879 --> 00:03:59,639 We pass our experience on to the next generation of scientists. 49 00:04:02,360 --> 00:04:06,599 We are pleased that the results of our basic and applied research 50 00:04:06,960 --> 00:04:10,680 find applications in medicine, agriculture, industry, 51 00:04:11,000 --> 00:04:13,120 and environmental protection.